How Cancer Shaped Justice Ruth Bader Ginsburg’s Life and Work

The name Ruth Bader Ginsburg became almost synonymous with strength and stamina as she rose to prominence in judicial and feminist circles throughout her long career. Famously nicknamed the Notorious RBG and known for her grueling fitness regimen, the late Supreme Court justice also struggled with cancer and other health issues for the better part of her time on the bench — culminating with her death on Sept. 18 at the age of 87 of complications from metastatic pancreatic cancer.Ginsburg’s health issues became public in 1999, six years after her appointment to the Supreme Court, when she had surgery for early-stage colon cancer. Ten years later, she went through the same process for pancreatic cancer. And nearly a decade after that, the Supreme Court announced that Ginsburg had undergone surgery to have two cancerous growths removed from her left lung. She announced in July 2020 that she’d been treated earlier that year for cancerous lesions on her liver, but made clear her intentions…

Gilead is Testing Inahalable Remdesivir, as a Possible Replacement for the Intravenous Form of the Drug

On June 22, Gilead, the California-based pharmaceutical company that makes remdesivir, said it will start testing an inhaled form of its experimental COVID-19 therapy. Currently, patients can only receive the drug by IV infusion provided under the supervision of medical experts.

In a letter published to the company’s website, chairman and CEO David O’Day said Gilead will begin screening healthy volunteers this week to participate in a phase 1 trial of a nasally administered version of remdesivir. Phase 1 trials are designed to determine the safety of an experimental treatment, before moving on to studies of its effectiveness.

The IV-administered form of remdesivir is still being tested, along with other drugs, among the sickest patients who are hospitalized for COVID-19. Early data from those studies suggest that remdesivir can help patients recover more quickly compared to patients not receiving the infusions. Because the drug is not yet approved; patients can only receive it either by participating in a trial or, if they are severely ill, through an emergency use authorization from the U.S. Food and Drug Administration (which allows doctors to prescribe the drug if no other therapies have worked).

The company also announced in its June 22 letter that it will investigate using remdesivir in COVID-19 patients with less severe symptoms, in the hopes that introducing the drug earlier in the disease may help some people avoid the worst symptoms of respiratory distress and failure.

Source: Gilead is Testing Inahalable Remdesivir, as a Possible Replacement for the Intravenous Form of the Drug


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