Over the past year, the coronavirus weaseled its way onto the list of the most common causes of death—and it's still a threat. Knowing the signs of the top 5 other deadliest diseases you could develop could be a matter of life or death. Read on for this latest list from the CDC—and to ensure your health and the health of others, don't miss these Sure Signs You Have "Long" COVID and May Not Even Know It . 1 You May Have Heart Disease "A buildup of fatty plaques in your arteries, or atherosclerosis (ath-ur-o-skluh-ROE-sis) can damage your blood vessels and heart," according to the Mayo Clinic . "Plaque buildup causes narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke. Coronary artery disease symptoms may be different for men and women. For instance, men are more likely to have chest pain. Women are more likely to have other signs and symptoms along with chest discomfort, such as shortness of breath